In the last few months the Novel Coronavirus has been reported as possibly linked to a paediatric hyper-inflammatory syndrome. A small number of children have developed a more serious inflammatory condition in temporal association with COVID-19 in the community, often leading to hospitalization, and occasionally requiring intensive care.

In order to better characterize this new clinical phenotype, few month ago a joined PReS, ESID, ISSAID, ERN-RITA and PRINTO network’s effort has been started; an international survey has been launched asking the number of patients seen at with this clinical phenotype, the total number is now 475 from 87 pediatric centers in the world.



We are now happy to inform you that the project called HyperPED-COVID, a retrospective observational study, has now started and the first patients have been entered in the websystem.



For any further information on how to participate and on site activation please contact printo@gaslini.org

Marco Gattorno (Coordinator, RITA-ERN & ISSAID)

Nico Wullfraat (RITA-ERN), Sefi Uziely, Fabrizio De Benedetti (PRES research clinical affairs), Paul Brogan (ISSAID), Carine Wouters (ERN-RITA),

Claudia Bracaglia and Francesca Minoia (PRES MAS/sJIA working party)

Roberta Caorsi, Alessandro Consolaro (Survey Coordinators)

Nicola Ruperto and Alberto Martini for PRINTO

Caorsi R, Consolaro A, Speziani C, Sozeri B, Ulu K, Faugier-Fuentes E, Menchaca-Aguayo H, Ozen S, Sener S, Akhter Rahman S, Islam MI, Haerynck F, Simonini G, Mastri MV, Avcin T, Sršen S, Pedrosa Fernandes TA, Stanevicha V, Vojinovic J, Sobh A, Fingerhutova S, Minxova L, Gagro A, Rodrigues Fonseca A, Pandya D, Varbanova B, Sánchez-Manubens J, Ganeva M, Montin D, Boyarchuk O, Minghini A, Bracaglia C, Brogan P, Candotti F, Cattalini M, Meyts I, Minoia F, Taddio A, Wouters C, De Benedetti F, Bovis F, Ravelli A, Ruperto N, Gattorno M, HyperPED-COVID study group, ERN-RITA (European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases), PReS (Pediatric Rheumatology European Society), ESID (European Society for Immunodeficiencies), ISSAID (International Society of Systemic Auto-Inflammatory Diseases) and the Paediatric Rheumatology International Trials Organisation (PRINTO)
The HyperPed-COVID international registry: Impact of age of onset, disease presentation and geographical distribution on the final outcome of MIS-C
J Autoimmun Volume 147 , July 2024, 103265
Year: 2024 -

 Ask for reprints