Thanks to a second grant from the European Union (Contract no. QLG1-CT-2000-00514 2000-2003) we set up a project to define core sets of outcome measures for disease activity and disease damage assessment and definitions of improvement, to be used in clinical trials and outcome assessment studies in children with juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). This project was developed in collaboration with the US-based “Pediatric Rheumatology Collaborative Study Group (PRCSG). The project has collected 292 patients with JDM and 554 patients with JSLE from 41 countries.The final goal of this project is to have a standardised approach for the outcome evaluation of children with JSLE and JDM enrolled in clinical trials.

Rosina S, Consolaro A, van Dijkhuizen P, Pistorio A, Varnier GC, Bovis F, Nistala K, Maillard S, Civino A, Tsitsami E, de Inocencio J, Jelusic M, Vojinovic J, Espada G, Makay B, Katsicas MM, Pratsidou-Gertsi P, Lazarevic D, Rao AP, Pires Marafon D, Martini A, Pilkington C, Ruperto N, Ravelli A. for the Pediatric Rheumatology International Trials Organization (PRINTO)
Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis
Rheumatology 2019 Jul 1;58(7):1196-1205
Year: 2019 -

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Brunner HI, Holland MJ, Beresford MW, Ardoin SP, Appenzeller S, Silva CA, Flores F, Goilav B, Avar Aydin PO, Wenderfer SE, Levy DM, Ravelli A, Khubchandani R, Avcin T, Klein-Gitelman MS, Ruperto N, Feldman BM, Ying J for the Paediatric Rheumatology International Trial Organisation and the Pediatric Rheumatology Collaborative Study Group
The American College of Rheumatology Provisional criteria for clinically relevant improvement in children & adolescents with childhood-onset systemic lupus erythematosus
Arthritis Care Res 2019;71(5):579-590
Year: 2019 -

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Brunner HI, Holland M, Beresford MW, Ardoin SP, Appenzeller S, Silva CA, Flores F, Goilav B, Wenderfer SE, Levy DM, Ravelli A, Khunchandani R, Avcin T, Klein-Gitelman MS, Feldman BM, Ruperto N, Ying J, for the PRCSG and PRINTO Investigators
American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus
Arthritis Care Res 2018 Jun;70(6):813-822
Year: 2018 -

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Holland MJ, Beresford MW, Feldman BM, Huggins J, Norambuena X, Silva CA, Susic G, Sztajnbok F, Uziel Y, Appenzeller S, Ardoin SP, Avcin T, Flores F, Goilav B, Khubchandani R, Klein-Gitelman M, Levy D, Ravelli A, Wenderfer SE, Ying J, Ruperto N, Brunner HI; for Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus.
Arthritis Care Res 2018 Nov; 70(11):1621–1629
Year: 2018 -

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Lazarevic D, Pistorio A, Palmisani E, Miettunen P, Ravelli A, Pilkington C, Wulffraat N, Malattia C, Garay S, Hofer M, Quartier P, Dolezalova P, Calvo I, Ferriani V, Ganser G, Kasapcopur O, Melo-Gomes JA, Reed AM, Wierzbowska M, Rider LG, Martini A, Ruperto N for the Paediatric Rheumatology International Trials Organisation (PRINTO).
The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis.
Ann Rheum Dis 2013;72:686-693
Year: 2013 -

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Miettunen PM, Pistorio A, Palmisani E, Ravelli A, Silverman E, Oliveira S, Alessio M, Cuttica R, Mihaylova D, Espada G, Pasic S, Insalaco A, Ozen S, Porras O, Sztajnbok F, Lazarevic D, Martini A, Ruperto N for PRINTO.
Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus erythematosus: an international multicenter PRINTO study.
Ann Rheum Dis 2013;72:1503-1509
Year: 2013 -

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Rygg M, Pistorio A, Ravelli A, Maghnie M, Di Iorgi N, Bader-Meunier B, Da Silva C, Roldan-Molina R, Barash J, Dracou C, Gandom Laloum S, Jarosova K, Job Deslandre C, Kone-Paut I, Garofalo F, Press J, Sengler C, Tauber T, Martini A, Ruperto N for the Paediatric Rheumatology International Trials Organisation (PRINTO).
A longitudinal printo study on growth and puberty in juvenile systemic lupus erythematosus
Ann Rheum Dis 2012;71:511-517
Year: 2012 -

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Hasija R, Pistorio A, Ravelli A, Demirkaya E, Khubchandani R, Guseinova D, Malattia C, Canhao H, Harel L, Foell D, Wouters C, De Cunto C, Huemer C, Kimura Y, Mangge H, Minetti C, Nordal EB, Philippet P, Garozzo R, Martini A, Ruperto N for the Paediatric Rheumatology International Trials Organisation (PRINTO).
Therapeutic approaches in the treatment of juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease flare. An international multicenter PRINTO study.
Arthritis Rheum 2011;63(10);3142-3152
Year: 2011 -

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Ruperto N, Bazso A, Pistorio A, Ravelli A, Filocamo G, Hernandez Huirache HG, Rodriguez Lozano AK, Pringe AB, Vilca I, Martini A for the Pediatric Rheumatology International Trials Organisation (PRINTO).
Agreement between multi-dimensional and renal-specific response criteria in patients with juvenile systemic lupus erythematosus and renal disease.
Clin Exp Rheumatol. 2010;28:424-433.
Year: 2010 -

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Ruperto N, Pistorio A, Ravelli A, Rider LG, Pilkington C, Oliveira S, Wulffraat N, Espada G, Garay S, Cuttica R, Hofer M, Quartier P, Melo-Gomes J, Reed AM, Wierzbowska M, Feldman BM, Harjacek M, Huppertz HI, Nielsen S, Flato B, Lahdenne P, Michels H, Murray KJ, Punaro L, Rennebohm R, Russo R, Balogh Z, Rooney M, Pachman LM, Wallace C, Hashkes P, Lovell DJ, Giannini EH, Martini A for the Pædiatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).
The Pediatric Rheumatology International Trials Organization provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis.
Arthritis Care Res 2010;62:1533-1541
Year: 2010 -

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Ruperto N, Pistorio A, Ravelli A, Hasija R, Guseinova D, Filocamo G, Demirkaya E, Malattia C, Martini A for the Paediatric Rheumatology International Trials Organisation (PRINTO).
Criteria to define response to therapy in paediatric rheumatic diseases.
Eur J Clin Pharmacol 2011;67(Suppl 1):S125-S131
Year: 2010 -

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Apaz MT, Saad-Magalhães C, Pistorio A, Ravelli A, de Oliveira Sato J, Marcantoni MB, Meiorin S, Filocamo G, Pilkington C, Maillard S, Al-Mayouf S, Prahalad S, Fasth A, Joos R, Schikler K, Mozolova D, Landgraf JM, Martini A, Ruperto N; for the Paediatric Rheumatology International Trials Organisation (PRINTO).
Health-related quality of life of patients with juvenile dermatomyositis: Results from the paediatric rheumatology international trials organisation multinational quality of life cohort study.
Arthritis Rheum 2009;61(4):509-17
Year: 2009 -

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Ruperto N, Ravelli A, Pistorio A, Ferriani V, Calvo I, Ganser G, Brunner J, Dannecker G,Silva CA, Stanevicha V, Ten Cate R, Van Suijlekom-Smit LWA, Voygioyka O, Fischbach M, Foeldvari I, Hilario MO, Modesto C, Saurenmann RK, Sauvain MJ, Scheibel I, Sommelet D, Tambic-Bukovac L, Barcellona R, Brik R, Ehl S, Jovanovic M, Rovensky J, Bagnasco F, Lovell DJ, Martini A, for the Pediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).
The Provisional Pediatric Rheumatology International Trial Organization/American College of Rheumatology Disease Activity Core Set for the evaluation of response to therapy in Juvenile Dermatomyositis: A Prospective validation study.
Arthritis Rheum 2008; 59:4-13.
Year: 2008 -

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Meiorin S, Pistorio A, Ravelli A, Iusan SM, Filocamo G, Trail L, Oliveira S, Cuttica R, Espada G, Alessio M, Mihaylova D, Cortis E, Martini A, Ruperto N, for the Pædiatric Rheumatology International Trials Organisation (PRINTO).
Validation of the Childhood Health Assessment Questionnaire in active juvenile systemic lupus erythematosus.
Arthritis Rheum 2008; 59:1112-1119
Year: 2008 -

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Ruperto N, Pistorio A, Ravelli A, Martini A, for the Pædiatric Rheumatology International Trials Organisation (PRINTO).
Reply to the letter by Rider et al.
Arthritis Rheum 2008;59:1198-1199
Year: 2008 -

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Ruperto N, Ravelli A, Oliveira S, Alessio M, Mihaylova D, Pasic S, Cortis E, Apaz M, Burgos-Vargas R, Kanakoudi-Tsakalidou F, Norambuena X, Corona F, Gerloni V, Hagelberg S, Aggarwal A, Dolezalova P, Magalhaes Saad C, Bae SC, Vesely R, Avcin T, Foster H, Duarte C, Herlin T, Horneff G, Lepore L, Van Rossum M, Trail L, Pistorio A, Andersson-Gäre B, Giannini EH, Martini A, for the Pædiatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).
The Pediatric Rheumatology International Trials Organization/American College of Rheumatology provisional criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus. Prospective validation of the definition of improvement.
Arthritis Rheum 2006; 55:355-363
Year: 2006 -

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Raul Gutiérrez-Suárez, Nicolino Ruperto, Roberto Gastaldi, Angela Pistorio, Enrico Felici, Ruben Burgos-Vargas, Alberto Martini, and Angelo Ravelli, for the Pediatric Rheumatology International Trials Organization (PRINTO)
A Proposal for a Pediatric Version of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index Based on the Analysis of 1,015 Patients With Juvenile-Onset Systemic Lupus Erythematosus
Arthritis Rheum 2006;54(9):2989–2996
Year: 2006 -

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Ruperto N, Ravelli A, Martini A
Reply to letter by Isenberg and Gordon commenting on the Pediatric Rheumatology International Trials Organization criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus.
Arthritis Rheum Oct 30;54(11):3723-3724
Year: 2006 -

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Ruperto N, Ravelli A, Martini A, for the Pædiatric Rheumatology International Trials Organisation (PRINTO).
Evaluation of renal improvement in juvenile systemic lupus erythematosus: Comment on the articles by Ruperto et al. Reply.
Arthritis Rheum 2006;55:991-992
Year: 2006 -

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Ruperto N, Ravelli A, Cuttica R, Espada G, Ozen S, Porras O, Sztajnbok F, Falcini F, Kasapcopur O, Venning H, Bica B, Merino R, Coto V, Ros J, Susic G, Gamir ML, Minden K, See Y, Uziel Y, Mukamel M, Riley P, Zulian F, Olivieri AN, Cimaz R, Girschick H, Rumba I, Cavuto S, Pistorio A, Lovell DJ, Martini A, for the Pædiatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).
The PRINTO criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus. Prospective validation of the core set.
Arthritis Rheum 2005;52(9):2854-2864
Year: 2005 -

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Ruperto N, Ravelli A, Murray KJ, Lovell DJ, Andersson-Gare B, Feldman BM, Garay S, Kuis W, Machado C, Pachman L, Prieur AM, Rider LG, Silverman E, Tsitsami E, Woo P, Giannini EH, Martini A for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG).
Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis.
Rheumatology 2003; 42: 1452-1459
Year: 2003 -

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